For Alzheimer’s disease, the most commonly prescribed drugs are choline-based drugs.
Mode of Action: Prevention of acetylcholine breakdown.
Major Cholinergic Drugs: Donepezil, rivastigmine, galantamine.
Noncholinergic drugs: Memantine (NMDA receptor antagonists).
Limitations: Temporary relief of symptoms (memory degradation), only partial delay in disease progression.
Unmet needs: Fundamentally treat or delay the disease progress without serious side effects.
2015: $ 3,299 million (estimated)
2020: $ 2,291 million (estimated)
2024: $ 5,449 million (estimated)
Alzheimer’s disease is the most common type of neurodegenerative diseases and is known to have a host of multifactorial pathogenesis mechanisms.At BIOGRAPHENE, we target the fibrillation of misfolded amyloid beta (Ab) and associated tau pathology.